Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)

Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)

Blog Article

Purpose: Examine the use of systemic phosphodiesterase inhibition (sildenafil) to clear central serous chorioretinopathy Circuit Breaker (CSCR).Observations: In a long-standing CSCR patient, sildenafil produced a rapid resolution.When discontinued (dechallenge) the CSCR returned.When rechallenged, the CSCR again 929 rapidly disappeared and did not recur in 5 months of continued therapy.

Conclusions: AND IMPORTANCE: Systemic sildenafil can cause rapid clearance of CSCR and can augment or replace other treatments.